Artículos

Immunothrombosis: Molecular Aspects and New Therapeutic Perspectives

María Marcos-Jubilar¹, Ramón Lecumberri^1,2, José A. Páramo^1,3,*

1. Hematology and Hemotherapy Service, Clínica Universidad de Navarra, 31008 Pamplona, Spain
2. CIBER-CV, Instituto de Salud Carlos III, 28029 Madrid, Spain
3. Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain

* Author to whom correspondence should be addressed

J. Clin. Med. 2023, 12, 1399. https://doi.org/10.3390/jcm12041399 Published: 9 February 2023 · Immunothrombosis-JCM.pdf

Abstract

Thromboinflammation or immunothrombosis is a concept that explains the existing link between coagulation and inflammatory response present in many situations, such as sepsis, venous thromboembolism, or COVID-19 associated coagulopathy. The purpose of this review is to provide an overview of the current data regarding the mechanisms involved in immunothrombosis in order to understand the new therapeutic strategies focused in reducing thrombotic risk by controlling the inflammation.

Keywords: immunothrombosis; thromboinflammation; tissue factor

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